Announcements

Index Semi-Annual Reconstitution (Final) - June 2020

June 11, 2020

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Tuesday, June 16, 2020. All positions will be equally weighted, with weights determined as of the closing prices on Friday, June 12, 2020. The final changes are summarized below.

LifeSci Biotechnology Clinical Trials Index

Additions (45 stocks):

ADAP, APLT, APRE, ARQT, BCEL, BDTX, BNTX, BTAI, CALA, CGEN, CRNX, CUE, DVAX, EDIT, FREQ, HARP, IGMS, KNSA, KZR, MEIP, MIRM, MRNS, MRSN, MTEM, NGM, NTLA, NVAX, OVID, OYST, PHAT, PRTA, PRVL, PTGX, RAPT, RCUS, RLMD, RUBY, RVMD, SELB, SNDX, SYRS, VIE, VIR, VSTM, XENE

Deletions (8 stocks):

AUTL, GLYC, PGNX, UBX (no longer fit index criteria)
BPMC, EPZM, ESPR, IMMU (being moved to Products Index based on FDA approval)

Summary:

The updated index will have 130 equal-weighted components (previously 93)
As of 6/11/2020, the average market cap is approximately $1.7 billion, and the median market cap is approximately $1.0 billion.

LifeSci Biotechnology Products Index

Additions (4 stocks):

BPMC, EPZM, ESPR, IMMU (being moved from Clinical Trials Index)

Deletions (3 stock):

LXRX, PTLA, STML

Summary:

The updated index will have 45 equal-weighted components (previously 44)
As of 6/11/2020, the average market cap is approximately $13.9 billion, and the median market cap is approximately $3.6 billion.

The LifeSci Biotechnology Indexes are equal-weighted indexes that track the performance of U.S.-listed biotechnology stocks in two distinct stages in the lifecycle of biotechnology companies – Clinical Trials stage and Product stage. The indexes are calculated with a base value of 1,000 as of June 30, 2004 and have an official inception date of November 3, 2014.

LifeSci Biotechnology Clinical Trials Index – All Components (Final) as of June 16, 2020

ADAP, ADVM, AGEN, AKBA, AKRO, ALEC, ALLK, ALLO, AMRS, ANAB, APLS, APLT, APRE, ARDX, ARNA, ARQT, ARVN, ARWR, ASMB, ASND, ATNX, ATRA, AVRO, AXSM, BBIO, BCEL, BCRX, BDTX, BHVN, BLUE, BNTX, BTAI, CALA, CARA, CCXI, CGEN, CNST, CRBP, CRNX, CRSP, CRTX, CTMX, CUE, CVM, CYTK, DCPH, DNLI, DRNA, DTIL, DVAX, EDIT, EIDX, FATE, FGEN, FIXX, FREQ, GERN, GOSS, GTHX, HARP, IGMS, IMGN, IOVA, ITCI, KDMN, KNSA, KOD, KRTX, KRYS, KURA, KZR, MDGL, MEIP, MGNX, MGTX, MIRM, MRNA, MRNS, MRSN, MRTX, MTEM, MYOK, MYOV, NGM, NTLA, NVAX, NXTC, ODT, ORTX, OVID, OYST, PHAT, PRNB, PRTA, PRVB, PRVL, PTGX, QURE, RAPT, RCKT, RCUS, RETA, RGNX, RIGL, RLMD, RUBY, RVMD, RYTM, SELB, SGMO, SNDX, SRNE, SWTX, SYRS, TBIO, TCDA, TGTX, TPTX, VIE, VIR, VKTX, VSTM, VYGR, WVE, XBIT, XENE, XNCR, YMAB, ZIOP, ZYME

LifeSci Biotechnology Products Index – All Components (Final) as of June 16, 2020

ACAD, AGIO, AIMT, AKCA, ALNY, ALXN, AMGN, BGNE, BIIB, BMRN, BPMC, CLVS, ENTA, EPZM, ESPR, EXEL, FOLD, GBT, GILD, HALO, ICPT, IMMU, INCY, INSM, IONS, IRWD, KPTI, LGND, MNTA, NBIX, NKTR, OMER, PTCT, RARE, RDUS, REGN, RTRX, SAGE, SGEN, SRPT, TBPH, UTHR, VNDA, VRTX, XLRN

For more information, visit www.lifescietf.com