Announcements

Index Semi-Annual Reconstitution (Final) - December 2020

December 14, 2020

LifeSci Biotechnology Products Index

LifeSci Biotechnology Clinical Trials Index

The LifeSci Biotechnology Products Index and the LifeSci Biotechnology Clinical Trials Index will be reconstituted as of the market open on Wednesday, December 16, 2020. All positions will be equally weighted, with weights determined as of the closing prices on Monday, December 14, 2020. The final changes are summarized below.

LifeSci Biotechnology Clinical Trials Index

Additions (45 stocks):

ADCT, AFMD, ALBO, ALVR, ALXO, AMTI, ANNX, ARCT, CDXS, CLDX, COGT, CRDF, CVAC, ETNB, FMTX, FPRX, GMDA, HGEN, IMAB, IMTX, IMVT, INBX, INO, ISEE, ITOS, KROS, LEGN, MCRB, MORF, NK, NKTX, ORIC, PGEN, PLRX, REPL, RLAY, RNA, RPTX, SRRK, STOK, STRO, TCRR, UROV, VXRT, ZNTL

Deletions (10 stocks):

CRBP, OVID, ASMB (no longer fit index criteria)
BHVN, BNTX, DCPH, ITCI, MRNA, VIE, YMAB (being moved to Products Index based on FDA approval)

Summary:

The updated index will have 163 equal-weighted components (previously 128)
As of 12/14/2020, the average market cap is approximately $2.1 billion, and the median market cap is approximately $1.2 billion.

LifeSci Biotechnology Products Index

Additions (8 stocks):

BHVN, BNTX, DCPH, HRMY, ITCI, MRNA, VIE, YMAB

Deletions (1 stock):

CLVS

Summary:

The updated index will have 48 equal-weighted components (previously 41)
As of 12/14/2020, the average market cap is approximately $15.1 billion, and the median market cap is approximately $5.5 billion.

The LifeSci Biotechnology Indexes are equal-weighted indexes that track the performance of U.S.-listed biotechnology stocks in two distinct stages in the lifecycle of biotechnology companies – Clinical Trials stage and Product stage. The indexes are calculated with a base value of 1,000 as of June 30, 2004 and have an official inception date of November 3, 2014.

LifeSci Biotechnology Clinical Trials Index – All Components (Final) as of December 16, 2020

ADAP, ADCT, ADVM, AFMD, AGEN, AKBA, AKRO, ALBO, ALEC, ALLK, ALLO, ALVR, ALXO, AMRS, AMTI, ANAB, ANNX, APLS, APLT, APRE, ARCT, ARDX, ARNA, ARQT, ARVN, ARWR, ASND, ATNX, ATRA, AVRO, AXSM, BBIO, BCEL, BCRX, BDTX, BLUE, BTAI, CALA, CARA, CCXI, CDXS, CGEN, CLDX, CNST, COGT, CRDF, CRNX, CRSP, CRTX, CTMX, CUE, CVAC, CVM, CYTK, DNLI, DRNA, DTIL, DVAX, EDIT, EIDX, ETNB, FATE, FGEN, FIXX, FMTX, FPRX, FREQ, GERN, GMDA, GOSS, GTHX, HARP, HGEN, IGMS, IMAB, IMGN, IMTX, IMVT, INBX, INO, IOVA, ISEE, ITOS, KDMN, KNSA, KOD, KROS, KRTX, KRYS, KURA, KZR, LEGN, MCRB, MDGL, MEIP, MGNX, MGTX, MIRM, MORF, MRNS, MRSN, MRTX, MTEM, MYOV, NGM, NK, NKTX, NTLA, NVAX, NXTC, ODT, ORIC, ORTX, OYST, PGEN, PHAT, PLRX, PRTA, PRVB, PRVL, PTGX, QURE, RAPT, RCKT, RCUS, REPL, RETA, RGNX, RIGL, RLAY, RLMD, RNA, RPTX, RUBY, RVMD, RYTM, SELB, SGMO, SNDX, SRNE, SRRK, STOK, STRO, SWTX, SYRS, TBIO, TCDA, TCRR, TGTX, TPTX, UROV, VIR, VKTX, VSTM, VXRT, VYGR, WVE, XBIT, XENE, XNCR, ZIOP, ZNTL, ZYME

LifeSci Biotechnology Products Index – All Components (Final) as of December 16, 2020

ACAD, AGIO, ALNY, ALXN, AMGN, BGNE, BHVN, BIIB, BMRN, BNTX, BPMC, DCPH, ENTA, EPZM, ESPR, EXEL, FOLD, GBT, GILD, HALO, HRMY, ICPT, INCY, INSM, IONS, IRWD, ITCI, KPTI, LGND, MRNA, NBIX, NKTR, OMER, PTCT, RARE, RDUS, REGN, SAGE, SGEN, SRPT, TBPH, TVTX, UTHR, VIE, VNDA, VRTX, XLRN, YMAB